Aggressive T-cell Large Granular Lymphocytic Leukemia Presenting as an EBV Negative Post-Transplant Lymphoproliferative Disorder
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چکیده
A 33 year-old man, a renal transplant recipient, developed an aggressive T-cell large granular lymphocytic leukemia (LGL) that presented as a soft-tissue lesion, mimicking an abscess. The tumor cells showed cytological features of large granular lymphocytes, immunophenotypically characterized as mature T-cells expressing CD2, CD5, CD4, CD56, and TIA-1. About 80% of tumor cells were positive for Ki-67 and p53. Cytogenetic analysis demonstrated trisomy 8, trisomy 15, and trisomy 21. There was no evidence of Epstein-Barr virus infection. The patient died 14 days after diagnosis with multiple organ failure and extensive bone marrow and visceral involvement.
منابع مشابه
Large granular lymphocytic leukemia presenting late after solid organ transplantation: a case series of four patients and review of the literature.
Post-transplantation lymphoproliferative disorder (PTLD) is a significant complication of solid organ transplantation. Most PTLD is of the B-cell subtype, although T-cell subtype PTLD uncommonly occurs. T-cell PTLDs are usually aggressive neoplasms and shorten patient and allograft survivals significantly. We present a single-center case series of 4 patients who developed T-cell large granular ...
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